UVB narrow band with UVA for assist the healing process of many skin diseases and stimulate the production of health hormones. The UVA and UVB are stimulators of D vitamin, crucial for strengthening the natural immune system
We can find the phototerapy benefict of UV rays in many scientific books, with a lot of beneficts for many skin deseas or hormonal dysfunction, like:
A very important case study was carried out on Irish patients undergoing narrow band UVB treatment for psoriasis. Up to 75% of Irish people are vitamin D deficient in the winter months, and this study showed that serum 25 (OH) D levels increased significantly from a median of 23 ng / mL to 59 ng / mL compared to control group that had no change. Hence, the increase of 25 (OH) D was a beneficial side effect to the success of the treatment for psoriasis. However, based on the results of this study, the authors failed to link the increase in 25 (OH) D levels to the clearance of psoriasis, because there was no correlation with the response to treatment. Therefore, the improvement of 25 (OH) D and psoriasis are simultaneous but disconnected. The most sensible motivation is therefore to be found in the intradermal production of the active form of vitamin D, i.e. calcitriol (1.25 (OH) 2D). Confirmation comes from another study, where the positive result in the treatment of psoriasis by UVB radiation at close range (311nm), is partially connected to the anti-proliferative and differentiation action of calcitriol on keratinocytes. Another very interesting study confirmed the increase of 25 (OH) D by narrow band UVB phototherapy, but only in patients with low initial levels. This is very important because the production of vitamin D through exposure to UVB radiation is self-regulating, and prevents its potentially harmful accumulation. The use of 'narowband' narrowband technology allows for faster clearance of psoriatic plaques with a longer lasting effect than broadband technology.
The most effective treatments mainly use a mix of UVB and UVA, with which there is a clearance or a clear improvement in 90% of patients. The treatment can be adjuvanted by a pharmacological treatment with corticosteroids, which can also allow a reduction of UVB exposure.
First-line therapy concerns corticosteroids if the area is limited, but with an affected surface that exceeds 20% of the body, phototherapy is practically a must, with greater success in the face area. Phototherapy can lead to repigmentation, which occurs as a result of the activation, proliferation and migration of melanocytes into the epidermis, where they form perifollicular pigmentation islands. Usually PUVA or UVB is used. The narrowband UVB has been very successful in recent years, and many have highlighted mechanisms of action and procedures to make therapy more effective.
The lesions caused by this pathology occur frequently in areas of the body not exposed to the sun. Therefore, phototherapy has proven to be very effective, both using UVA with photosensitizing agents, and through UVB narrowband, inducing apoptosis of T lymphocytes. A mix of UVA and UVB allows for maximum effectiveness.
Systemic scleroderma and sclerosis are complex diseases with extensive fibrosis secondary to a disturbance of collagen metabolism, vascular dysregulation and autoantibodies to various cellular antigens. Phototherapy is an effective therapeutic option, especially in the UVA1 form, which penetrates deeply and induces the expression of collagenase messenger RNA, the depletion of T cells and cytokines IL-1 and IL-6, and a neovascularization. The induction of collagenase leads to a reduction in the thickness of the sclerotic plaque, increasing the elasticity of the skin. UVA1 therapy, compared to a UVA with photosensitizer, has a lower probability of phototoxic reactions with a greater penetration of radiation
In addition to suppressing skin inflammation, UVB radiation also acts on the systemic one by modulating the adaptive immune response, by suppressing the pro-terogene response by Treg cells, preventing the development of atherosclerotic plaques.
Vitamin D regulates the production of catelicidin LL-37, which has antimicrobial effects and reduces the activity of endotoxins, while reducing the production of proinflammatory cytokines. The effect on endotoxins is of great help in the reduction of systemic inflammation and of all the chronic pathologies associated with it , (including also the metabolic syndrome), while the reduction of the cytokine storm allows to mitigate the effects of viruses flu. Therefore, phototherapy is the most effective strategy for producing the necessary amount of vitamin D, without the risk of any side effects deriving from a possible overdose linked to the integration.
UV radiation reduces inflammation and modulates the immune system through mechanisms both dependent and independent of vitamin D, making it fundamental in the prevention and treatment of intestinal inflammatory diseases, rheumatoid arthritis, multiple sclerosis: the researchers have shown that UVB band radiation narrow (311nm), suppresses the inflammatory response and prevents demyelination in the spinal cord. The protective effects are dependent on the activation of cutaneous Langherans cells, leading to an increase in the number of tolerogenic dendritic cells and a significant increase in Treg cells, which attenuate the general activation of T cells and suppress inflammation.
Obvious benefits also on other skin diseases such as: Lichen planus, Lichenoid pityriasis, Pinky pityriasis, Polymorphic erythema, Pimply, Prurigo nodularis, Lupus vulgaris, Pityriasis versicolor.
Many clinical case history showed the benefits of UV rays in preventing viral infections such as SARS-COVID-19 (SOURCE)
A device for medical or private practices. Over 600 watts of power only for UVA + UVB and 500 watts for red and infrared lights (broadband up to 4000 nm) in order to enhance the treatment, conferring energy with an enlargement of the abnormal Z3 zones. Including control software based on your skin type
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